Runda eliminatorie:
| Data |
Echipa 1 |
Echipa 2 |
Scor |
| 2022-02-15 | Sporting CP | Manchester City | 0-5 |
| 2022-02-15 | Paris SG | Real Madrid | 1-0 |
| 2022-02-16 | Red Bull Salzburg | Bayern Munich | 1-1 |
| 2022-02-16 | Inter Milan | Liverpool | 0-2 |
| 2022-02-22 | Villarreal | Juventus | 1-1 |
| 2022-02-22 | Chelsea | Lille | 2-0 |
| 2022-02-23 | Benfica | Ajax | 2-2 |
| 2022-02-23 | Atlético Madrid | Manchester United | 1-1 |
| 2022-03-08 | Bayern Munich | Red Bull Salzburg | 7-1 |
| 2022-03-08 | Liverpool | Inter Milan | 0-1 |
| 2022-03-09 | Manchester City | Sporting CP | 0-0 |
| 2022-03-09 | Real Madrid | Paris SG | 3-1 |
| 2022-03-15 | Ajax | Benfica | 0-1 |
| 2022-03-15 | Manchester United | Atlético Madrid | 0-1 |
| 2022-03-16 | Lille | Chelsea | 1-2 |
| 2022-03-16 | Juventus | Villarreal | 0-3 |
| Echipa 1 |
Echipa 2 |
Meciul 1 |
Meciul 2 |
Scor general |
| Sporting CP |
Manchester City |
0-5 (2022-02-15) |
0-0 (2022-03-09) |
0-5 |
| Paris SG |
Real Madrid |
1-0 (2022-02-15) |
1-3 (2022-03-09) |
2-3 |
| Red Bull Salzburg |
Bayern Munich |
1-1 (2022-02-16) |
1-7 (2022-03-08) |
2-8 |
| Inter Milan |
Liverpool |
0-2 (2022-02-16) |
1-0 (2022-03-08) |
1-2 |
| Chelsea |
Lille |
2-0 (2022-02-22) |
2-1 (2022-03-16) |
4-1 |
| Villarreal |
Juventus |
1-1 (2022-02-22) |
3-0 (2022-03-16) |
4-1 |
| Atlético Madrid |
Manchester United |
1-1 (2022-02-23) |
1-0 (2022-03-15) |
2-1 |
| Benfica |
Ajax |
2-2 (2022-02-23) |
1-0 (2022-03-15) |
3-2 |
Sferturi de finală:
| Data |
Echipa 1 |
Echipa 2 |
Scor |
| 2022-04-05 | Manchester City | Atlético Madrid | 1-0 |
| 2022-04-05 | Benfica | Liverpool | 1-3 |
| 2022-04-06 | Villarreal | Bayern Munich | 1-0 |
| 2022-04-06 | Chelsea | Real Madrid | 1-3 |
| 2022-04-12 | Real Madrid | Chelsea | 2-3 |
| 2022-04-12 | Bayern Munich | Villarreal | 1-1 |
| 2022-04-13 | Atlético Madrid | Manchester City | 0-0 |
| 2022-04-13 | Liverpool | Benfica | 3-3 |
| Echipa 1 |
Echipa 2 |
Meciul 1 |
Meciul 2 |
Scor general |
| Benfica |
Liverpool |
1-3 (2022-04-05) |
3-3 (2022-04-13) |
4-6 |
| Manchester City |
Atlético Madrid |
1-0 (2022-04-05) |
0-0 (2022-04-13) |
1-0 |
| Villarreal |
Bayern Munich |
1-0 (2022-04-06) |
1-1 (2022-04-12) |
2-1 |
| Chelsea |
Real Madrid |
1-3 (2022-04-06) |
3-2 (2022-04-12) |
4-5 |
Semifinale:
| Data |
Echipa 1 |
Echipa 2 |
Scor |
| 2022-04-26 | Manchester City | Real Madrid | 4-3 |
| 2022-04-27 | Liverpool | Villarreal | 2-0 |
| 2022-05-03 | Villarreal | Liverpool | 2-3 |
| 2022-05-04 | Real Madrid | Manchester City | 3-1 |
| Echipa 1 |
Echipa 2 |
Meciul 1 |
Meciul 2 |
Scor general |
| Manchester City |
Real Madrid |
4-3 (2022-04-26) |
1-3 (2022-05-04) |
5-6 |
| Liverpool |
Villarreal |
2-0 (2022-04-27) |
3-2 (2022-05-03) |
5-2 |
Finală:
| Data |
Echipa 1 |
Echipa 2 |
Scor |
| 2022-05-28 | Liverpool | Real Madrid | 0-1 |
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