[Grupa A] [Grupa B] [Grupa C] [Grupa D] [Grupa E] [Grupa F] [Grupa G] [Grupa H]
| Etapa | Data | Echipa 1 | Echipa 2 | Scor |
| 1 | 2021-09-15 | Liverpool | Milan | 3-2 |
| 1 | 2021-09-15 | Atlético Madrid | FC Porto | 0-0 |
| 2 | 2021-09-28 | Milan | Atlético Madrid | 1-2 |
| 2 | 2021-09-28 | FC Porto | Liverpool | 1-5 |
| 3 | 2021-10-19 | Atlético Madrid | Liverpool | 2-3 |
| 3 | 2021-10-19 | FC Porto | Milan | 1-0 |
| 4 | 2021-11-03 | Milan | FC Porto | 1-1 |
| 4 | 2021-11-03 | Liverpool | Atlético Madrid | 2-0 |
| 5 | 2021-11-24 | Liverpool | FC Porto | 2-0 |
| 5 | 2021-11-24 | Atlético Madrid | Milan | 0-1 |
| 6 | 2021-12-07 | FC Porto | Atlético Madrid | 1-3 |
| 6 | 2021-12-07 | Milan | Liverpool | 1-2 |
| Echipa: | Meciuri | Victorii | Egaluri | Înfrângeri | Golav | Puncte | |
| Liverpool | 6 | 6 | 0 | 0 | 17 | 6 | 18 |
| Atlético Madrid | 6 | 2 | 1 | 3 | 7 | 8 | 7 |
| FC Porto | 6 | 1 | 2 | 3 | 4 | 11 | 5 |
| Milan | 6 | 1 | 1 | 4 | 6 | 9 | 4 |
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